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        • 馬健( 研究員 、碩士生導師 、博士生導師 )
        • 性別:
        • 學歷:博士研究生畢業
        • 學位:博士學位
        • 所在單位:基礎醫學院
        • 職務:Professor




        個人簡介

        馬健,男,醫學博士,研究員,博士生導師?,F任中南大學腫瘤研究所副所長、非可控性炎癥與腫瘤湖南省重點實驗室副主任、湖南省免疫學會副理事長。本科畢業于湖南醫科大學,博士畢業于中南大學腫瘤研究所。入選教育部新世紀優秀人才支持計劃,獲得湖南省杰出青年基金資助。

        先后主持了7項國家自然科學基金,并參加了數項國家自然科學基金重點項目、973項目和863項目。論文發表在Advanced Science、Journal of Hematology & Oncology、Oncogene、International Journal of Cancer、Journal of Cell Science、Journal of Virology、Journal of Biological Chemistry、Journal of Immunology等雜志。參編專(譯)著5 部:《基于WWW的生物信息學應用指南》、《現代腫瘤學基礎》、《病理生理學》、《癌癥-基礎卷》和《非編碼RNA與腫瘤》。

        課題組主要研究方向

          (1) EB病毒感染與腫瘤免疫的機制研究。

          (2) 利用小鼠模型和臨床樣本,研究炎癥-惡性轉化過程中的關鍵分子、關鍵信號通路和可能的靶向策略。

          (3) 近年來對a) Hippo通路的YAP分子,b) 在腫瘤發生、發展中發揮重要功能的EphA2分子,c) 在天然免疫中發揮重要作用的天然免疫分子Lactoferrin進行了重點研究。

        Email: majian@csu.edu.cn

        近年發表的主要論文*為通訊作者):

        RPeng Q, Wang L, Wang J, Liu C, Zheng X, Zhang X, Wei L, Li Z, Wu Y, Wen Y, Cao P, Liao Q, Yan Q*, Ma J*. Epstein-Barr Virus EBNA2 Phase Separation Regulates Cancer-associated Alternative RNA Splicing Patterns. Clinical and Translational Medicine. 2021;11(8):e504. PMID: 34459139.

        1)      Ou C, Sun Z, He X, Li X, Fan S, Zheng X, Peng Q, Li G, Li X*, Ma J*.Targeting YAP1/LINC00152/FSCN1 signaling axis prevents the progression of colorectal cancer. Advanced Science. 2019; 7(3): 1901380. PMID: 32042551

        2)      Wei L, Liu C, Wang J, Zheng X, Peng Q, Ye Q, Qin Z, Li Z, Zhang X, Wu Y, Wen Y, Zhang X, Yan Q, Ma J*. Lactoferrin is required for early B cell development in C57BL/6 mice. Journal of Hematology & Oncology. 2021 Apr 7;14(1):58. PMID: 33827645.  

        3)      Wei L, Zhang X, Wang J, Ye Q, Zheng X, Peng Q, Zheng Y, Liu P, Zhang X, Li Z, Liu C, Yan Q, Li G, Ma J*. Lactoferrin deficiency induces a pro-metastatic tumor microenvironment through recruiting myeloid–derived suppressor cells in mice. Oncogene. Oncogene. 2020; 39(1): 122-135. PMID: 31462711

        4)      Zheng X, Wang J, Zhang X, Fu Y, Peng Q, Lu J. Wei L. Li Z, Liu C, Wu Y, Yan Q*, Ma J*. RNA m6A methylation regulates virus–host interaction and EBNA2 expression during Epstein–Barr virus infection. Immunity, Inflammation and Disease. 2021;9(2):351-362, PMID: 33434416. 

        5)      Peng Q, Wang L, Qin Z, Wang J, Zheng X, Wei L, Zhang X, Zhang X, Liu C, Li Z, Wu Y, Li G, Yan Q*, Ma J*. Phase separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP controls gene expression. Journal of Virology. 2020; 94(7): e01771-19. PMID: 31941785.  

        6)      Li Z, Wang J, Zhang X, Liu P, Zhang X, Wang J, Zheng X, Wei L, Peng Q, Liu C,Yan Q, Shen S, Li X*, Ma J*. Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape. Journal of Immunology. 2020 May 1;204(9):2589-2599. PMID: 32198140.  

        7)      Wang J, Zheng X, Qin Z, Wei L, Lu Y, Peng Q, Gao Y, Zhang X, Zhang X, Li Z, Fu Y, Liu P, Liu C, Yan Q, Xiong W, Li G, Lu J*, Ma J*. Epstein-Barr virus miR-BART3-3p promotes tumorigenesis by regulating the senescence pathway in gastric cancer. Journal of Biological Chemistry. 2019;294(13):4854–4866. PMID: 30674552

        8)      Zheng X, Wang J, Wei L, Peng Q, Gao Y, Fu Y, Lu Y, Qin Z, Zhang X, Lu J, Ou C, Li Z, Zhang X, Liu P, Xiong W, Li G, Yan Q, Ma J*. Epstein-Barr Virus miR-BART5-3p inhibits p53 expression. Journal of Virology. 2018; 92(23): e01022-18. PMID: 30209170.

        9)      Peng Q, Chen L, Wu W, Wang J, Zheng X, Chen Z, Jiang Q, Han J, Wei L, Wang L, Huang J*, Ma J*. EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer. Cell Death & Disease. 2018;9(12):1146. PMID: 30451837

        10)    Wang S, Song R, Wang Z, Jing Z, Wang S, Ma J*. S100A8/A9 in Inflammation. Frontiers in Immunology. 2018; 9:1298. PMID: 29942307.

        11)    Ou C, Sun Z, Li X, Li X, Ren W, Qin Z, Zhang X, Yuan W, Wang J, Yu W, Zhang S, Peng Q, Yan Q, Xiong W, Li G*, Ma J*. MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer. Cancer Letters. 2017; 399: 53-63. PMID: 28433598.

        12)    Zhang X, Wei L, Wang J, Qin Z, Wang J, Lu Y, Zheng X, Peng Q, Ye Q, Ai F, Liu P, Wang S, Li G, Shen S, Ma J*. Suppression colitis and colitis-associated colon cancer by anti-S100a9 antibody in mice. Frontiers in Immunology. 2017; 8:1774. PMID: 29326691  

        13)    Lu Y, Qin Z, Wang J, Zheng X, Lu J, Zhang X, Wei L, Peng Q, Zheng Y, Ou C, Ye Q, Xiong W, Li G, Fu Y, Yan Q*, Ma J*. Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway. Journal of Innate Immunity. 2017;9(6):574-586. PMID: 28877527.

        14)    Ren W, Shen S, Sun Z, Shu P, Shen X, Bu C, Ai F, Zhang X, Tang A, Tian L, Li G, Li X*, Ma J*. Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4ADCAF1 to promote colon cancer development. Cancer Letters. 2016; 375(2): 209-220. PMID: 26965998.

        15)    Qin Z, He W, Tang J, Ye Q, Dang W, Lu Y, Wang J, Li G, Yan Q*, Ma J*. MicroRNAs provide feedback regulation of epithelial-mesenchymal transition induced by growth factors. Journal of Cellular Physiology. 2016; 231(1):120-129. PMID: 26032086.

        16)    Zhang X, Ai F, Li X, She X, Li N, Tang A, Qin Z, Ye Q, Tian L, Li G, Shen S*, Ma J*. Inflammation-induced S100A8 activates Id3 and promotes colorectal tumorigenesis. International Journal of Cancer. 2015;137(12):2803-14. PMID: 26135667.

        17)    Zheng Y, Qin Z, Ye Q, Chen P, Wang Z, Yan Q, Luo Z, Liu X, Zhou Y, Xiong W, Ma J*, Li G*. Lactoferrin suppresses the Epstein-Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9. Laboratory Investigation.2014;94(11): 1188-1199. PMID: 25068657.  

        18)    Ye Q, Zheng Y, Fan S, Qin Z,Li N, Tang A, Ai F, Zhang X, Bian Y, Dang W, Huang J, Zhou M, Zhou Y, Xiong W, Yan Q, Ma J*, Li G*. Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice. PLoS One. 2014;9(7):e103298. PMID: 25057912.

        19)    Deng M, Zhang W, Tang H, YeQ, Liao Q, Zhou Y, Wu M, Xiong W, Zheng Y, Guo X, Qin Z, He W, Zhou M, Xiang J, Li X, Ma J(馬健)*, Li G*. Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms. Oncogene.2013; 32(36): 4273-4283. PMID: 23069661.

        20)    Tang A, Li N, Li X, Yang H,Wang W, Zhang L, Li GY, Xiong W, Ma J*, Shen S*. Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model. Carcinogenesis.2012, 33(7): 1375-1383. PMID: 22610167.

        21)    Zheng Y, Zhang W,Ye Q, ZhouY, Xiong W, He W, Deng M, Zhou M, GuoX, Chen P, Fan S, Liu X, Wang Z, Li X, Ma J*,Li G*. Inhibition of Epstein-Barr virus infection by lactoferrin. Journal of Innate Immunity. 2012,4(4): 387-398. PMID: 22433582.

        22)    Deng M, Tang H, Zhou Y, ZhouM, Xiong W, Zheng Y, Ye Q, Zeng X, Liao Q, Guo X, Li X, Ma J*, Li G*. MiR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma. Journal of Cell Science. 2011; 124(17): 2997-3005. PMID: 21878506.

         

         


        社會兼職
        • 2015.12-2019.12
           湖南省抗癌協會理事 

        • 2017.12-2020.12
           湖南省病理生理學會常務理事 

        • 2017.8-2022.8
           湖南省免疫學會副理事長 

        教育經歷
        • 1990.9-1995.7
           湖南醫科大學  |  預防醫學  | 學士學位   |  大學本科畢業

        • 1999.9-2004.6
           中南大學  |  病理學與病理生理學  | 博士學位   |  博士研究生畢業

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